Ferrocene-Based Compounds with Antimalaria/Anticancer Activity
Identifieur interne : 000816 ( Main/Exploration ); précédent : 000815; suivant : 000817Ferrocene-Based Compounds with Antimalaria/Anticancer Activity
Auteurs : Sijongesonke Peter ; Blessing Atim AderibigbeSource :
- Molecules [ 1420-3049 ] ; 2019.
Abstract
Malaria and cancer are chronic diseases. The challenge with drugs available for the treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent organometallic which have been hybridized with other compounds resulting in compounds with enhanced biological activity such as antimalarial and anticancer. Drugs such as ferroquine were developed from ferrocene and chloroquine. It was tested in the 1990s as an antimalarial and is still an effective antimalarial. Many researchers have reported ferrocene compounds as potent compounds useful as anticancer and antimalarial agents when hybridized with other pharmaceutical scaffolds. This review will be focused on compounds with ferrocene moieties that exhibit either an anticancer or antimalarial activity.
Url:
DOI: 10.3390/molecules24193604
PubMed: 31591298
PubMed Central: 6804011
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ferrocene-Based Compounds with Antimalaria/Anticancer Activity</title><author><name sortKey="Peter, Sijongesonke" sort="Peter, Sijongesonke" uniqKey="Peter S" first="Sijongesonke" last="Peter">Sijongesonke Peter</name></author><author><name sortKey="Aderibigbe, Blessing Atim" sort="Aderibigbe, Blessing Atim" uniqKey="Aderibigbe B" first="Blessing Atim" last="Aderibigbe">Blessing Atim Aderibigbe</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31591298</idno><idno type="pmc">6804011</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804011</idno><idno type="RBID">PMC:6804011</idno><idno type="doi">10.3390/molecules24193604</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000A68</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A68</idno><idno type="wicri:Area/Pmc/Curation">000A68</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A68</idno><idno type="wicri:Area/Pmc/Checkpoint">000757</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000757</idno><idno type="wicri:Area/Ncbi/Merge">000A84</idno><idno type="wicri:Area/Ncbi/Curation">000A84</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A84</idno><idno type="wicri:Area/Main/Merge">000816</idno><idno type="wicri:Area/Main/Curation">000816</idno><idno type="wicri:Area/Main/Exploration">000816</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ferrocene-Based Compounds with Antimalaria/Anticancer Activity</title><author><name sortKey="Peter, Sijongesonke" sort="Peter, Sijongesonke" uniqKey="Peter S" first="Sijongesonke" last="Peter">Sijongesonke Peter</name></author><author><name sortKey="Aderibigbe, Blessing Atim" sort="Aderibigbe, Blessing Atim" uniqKey="Aderibigbe B" first="Blessing Atim" last="Aderibigbe">Blessing Atim Aderibigbe</name></author></analytic><series><title level="j">Molecules</title><idno type="eISSN">1420-3049</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Malaria and cancer are chronic diseases. The challenge with drugs available for the treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent organometallic which have been hybridized with other compounds resulting in compounds with enhanced biological activity such as antimalarial and anticancer. Drugs such as ferroquine were developed from ferrocene and chloroquine. It was tested in the 1990s as an antimalarial and is still an effective antimalarial. Many researchers have reported ferrocene compounds as potent compounds useful as anticancer and antimalarial agents when hybridized with other pharmaceutical scaffolds. This review will be focused on compounds with ferrocene moieties that exhibit either an anticancer or antimalarial activity. </p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Glennon, E K K" uniqKey="Glennon E">E.K.K. Glennon</name></author><author><name sortKey="Dankwa, S" uniqKey="Dankwa S">S. 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Biersack</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aderibigbe, Blessing Atim" sort="Aderibigbe, Blessing Atim" uniqKey="Aderibigbe B" first="Blessing Atim" last="Aderibigbe">Blessing Atim Aderibigbe</name><name sortKey="Peter, Sijongesonke" sort="Peter, Sijongesonke" uniqKey="Peter S" first="Sijongesonke" last="Peter">Sijongesonke Peter</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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